@Article{MouraMOSMEAVPT:2020:SyEfAd,
               author = "Moura, Nayara Koba de and Martins, Eduardo Ferreira and Oliveira, 
                         Rodrigo Luiz Moraes Saldanha and Siqueira, Id{\'a}lia Aparecida 
                         Waltrick de Brito and Machado, Jo{\~a}o Paulo Barros and 
                         Esposito, Elisa and Amaral, Suelen Sim{\~o}es and Vasconcellos, 
                         Luana Marotta Reis de and Passador, Fabio Roberto and 
                         Trich{\^e}s, Eliandra de Sousa",
          affiliation = "{Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and {Instituto 
                         Nacional de Pesquisas Espaciais (INPE)} and {Universidade Federal 
                         de S{\~a}o Paulo (UNIFESP)} and {Universidade Estadual Paulista 
                         (UNESP)} and {Universidade Estadual Paulista (UNESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)}",
                title = "Synergistic effect of adding bioglass and carbon nanotubes on poly 
                         (lactic acid) porous membranes for guided bone regeneration",
              journal = "Materials Science and Engineering C",
                 year = "2020",
               volume = "117",
                pages = "e111327",
                month = "Dec.",
             keywords = "Poly (lactic acid), Bioglass, Carbon nanotubes, GBR, 
                         Antimicrobial.",
             abstract = "Polymer membranes have been widely used in guided bone 
                         regeneration (GBR), especially when it comes to their use in 
                         dentistry. Poly (lactic acid) (PLA) have good mechanical 
                         properties such as flexibility, which allows the material to be 
                         moldable and also has biocompatibility and biodegradation. Besides 
                         that, bioglass (BG) incorporated into the polymer matrix can 
                         promote osteoinduction properties and osteoconduction properties 
                         to the polymer-ceramic biocomposite. The membranes are also 
                         required to exhibit antimicrobial activity to prevent or control 
                         the proliferation of pathogenic microorganisms, and the addition 
                         of carbon nanotubes (CNT) can assist in this property. The porous 
                         membranes of PLA with the addition of different contents of BG and 
                         CNT were obtained by solvent casting in controlled humidity 
                         method, and the synergistic effect of the addition of both fillers 
                         were investigated. The membranes showed pores (311 \μm) on 
                         their surface. The addition of 5 wt% BG causes an increase in the 
                         surface porosity and bioactivity properties of the PLA. The agar 
                         diffusion test showed antimicrobial activity in the membranes with 
                         addition of CNT. In vitro results showed that the porous membranes 
                         were not cytotoxic and allowed cell activity and differentiation. 
                         Thus, BG collaborated to increase biological activity while CNT 
                         contributed to microbial activity, creating a synergistic effect 
                         on PLA porous membranes, being this effect more evident for 
                         PLA/5BG/1.0CNT. These results indicated a promising use of this 
                         new biomaterial for the production of porous membranes for GBR.",
                  doi = "10.1016/j.msec.2020.111327",
                  url = "http://dx.doi.org/10.1016/j.msec.2020.111327",
                 issn = "0928-4931",
             language = "en",
           targetfile = "moura_synergistic.pdf",
        urlaccessdate = "11 maio 2024"
}